Colleagues at Salford have recruited some of the first participants to an important NIHR-funded study looking at different types of pharmacological prophylaxis to reduce the risk of blood clots during temporary lower limb immobilisation after injury.
In the UK, around 70,000 people injure their leg and have to have wear a boot or a cast, putting them at higher risk of venous thromboembolism (VTE), which can cause long-term problems in the legs, serious illnesses, and occasionally death if the clot migrates to other parts of the body such as the lungs.
Professor Dan Horner is Chief Investigator for the TiLLI trial and Salford Royal is one of 12 planned pilot sites. Eventually, the study aims to recruit 10,000 patients in two linked studies across 30 sites. TiLLI-high will investigate what form of anticoagulant is better for people who are at high-risk of clots after a leg injury while TiLLI-low will look at what form of anticoagulant, if any, is better in people at low-risk of clots.