Pipette and test tubes

Role of bone marrow immune cells in Covid-19 revealed

White blood cells called monocytes released into the blood from bone marrow have abnormal features in people who have Covid-19, according to a new study.

The research shows the abnormalities are greater in patients with severe infection. By spotting the abnormal monocytes early, doctors may be able to predict which patients are more likely to develop severe disease.

The research was carried out by immunologists at The University of Manchester’s Lydia Becker Institute working with experts from the Northern Care Alliance’s Salford Royal and North Manchester General Hospital, as well as colleagues from Manchester University NHS Foundation Trust.

The team from the Coronavirus Immune Response and Clinical Outcome (CIRCO) consortium say the study provides the strongest evidence yet that monocytes may be an important therapeutic target for a Covid-19 treatment.

It is not yet clear, say the team, if abnormal monocytes are released from the bone marrow or if the changes happen after they enter the blood.

However, treatments preventing their release from bone marrow may help reduce the exaggerated immune response that contributes to poor outcomes in patients with severe Covid-19.

Scientists already know that monocytes – the largest type of white blood cell – are an important component in the lung during infection and play roles in protection and repair.

The team analysed over a hundred blood samples from Covid-19 patients admitted to four hospitals across Greater Manchester to search for biomarkers that signal progression to severe disease at various points in their hospital stay.

For researchers at Salford Royal and North Manchester General, the Northern Care Alliance Research Collection was essential to the study’s successful recruitment. To date, around 100 patients with Covid-19 have contributed to this biobank of tissue samples and data.

Dr John Grainger, Deputy Director of the Lydia Becker and a senior author on the study said: “Our work once again highlights the importance of the innate immune system in Covid-19, we’re excited to be able to finally share the results of our study and hope that it can better inform treatments for this devastating disease.”

Dr Sean Knight

Dr Sean Knight from Salford Royal (pictured) said: “This study highlights the importance of tissue biobanks in human research, as well as broad collaboration. Using the framework of the NCARC biobank allowed us to set up the project rapidly without compromising quality, which was essential for timing the study to capture the peak of the pandemic. Working with our colleagues at the University and MFT we were able to recruit and study a large number of people in a short space of time, which enabled us to uncover altered immune phenotypes that correlated with Covid-19 severity.”

The CIRCO consortium was set up during the first wave of the pandemic to collect longitudinal samples from patients with diagnosed Covid-19; studying their immune response from hospital admission through to outcome.

The study was in part supported by a rapid response Covid-19 award from The Kennedy Trust for Rheumatology Research

Professor Tracy Hussell, Director of the Lydia Becker Institute, added: “Thanks to all members of the CIRCO team for their hard work on this study it has been a great example of scientists and clinicians working together to give new insight into this infection.”

The paper Longitudinal immune profiling reveals key myeloid signatures associated with Covid-19 in the journal Science Immunology is the first to be published by the consortium.

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