Critical care teams at Bury, Oldham and Salford contributed to the UK-ROX study, with the results just published in JAMA and presented at the Critical Care Reviews meeting in Belfast.
This randomized clinical trial of 16,500 participants found no statistically significant difference between 90-day all-cause mortality after conservative oxygen therapy for critically ill adult ICU patients receiving mechanical ventilation and standard oxygen therapy.
It was one of the largest patient-level randomized trials in the history of critical care and a linked editorial in JAMA spotlights the way embedding enrolment within clinical care resulted in both a highly representative trial population and an ‘almost unprecedented level of efficiency’ in trial conduct.
Dr Ronan O’Driscoll is among the trial authors and Prof Dan Horner, Dr Redmond Tully, Dr Andrew Claxton, Dr Tim Fudge and Dr Tom Curtis were among the PIs and research leads. NCA recruited 474 patients to the study. The Oldham team who supported the study are pictured top.